The Gordan Lab is an interdisciplinary research group based in the Quantitative Biosciences Institute (QBI) at UCSF. Our research focuses on basic and translational questions in the treatment of liver cancers, combining innovative proteomic methods with unique patient-derived models to identify new therapeutic targets and markers of drug response. We have four major areas of investigation:
1. Overcoming the barriers to precision medicine in hepatocellular carcinoma
2. Targeting oncogenic Protein Kinase A signaling
3. Overcoming resistance to direct KRAS inhibitors in GI cancers
4. Investigating small molecule strategies to activate tumor suppressor signaling